| Autor: |
Potgieter, Peter D., Hammond, Janet M. J. |
| Zdroj: |
Drugs; June 1995, Vol. 49 Issue: Supplement 2 p86-91, 6p |
| Abstrakt: |
The new quinolone antimicrobial agents, particularly those with less activity against anaerobes, selectively prevent colonisation of the alimentary tract by Gram-negative bacilli and staphylococci without substantially affecting the normal anaerobic flora, which preserve the colonisation resistance of the gut. These properties ideally position this class of antibacterial agent for selective decontamination of the digestive tract (SDD) in the prevention of nosocomial infection. The rationale for this procedure is based on the presumption that a significant proportion of infections in compromised patients are endogenous in origin, arising from the host’s own microbial flora. If this colonisation by potentially pathogenic microflora within the normal flora can be significantly reduced without being replaced by other more pathogenic microorganisms, the risk of endogenous infection should be minimised. |
| Databáze: |
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