| Autor: |
Cappella, Lorenzo, Guerra, A., Laudizi, L., Cavazzuti, G. |
| Zdroj: |
Drugs; November 1993, Vol. 46 Issue: Supplement 1 p222-225, 4p |
| Abstrakt: |
In a single-blind study that recruited 70 children aged 5 to 12 years with acute upper respiratory tract infection and fever (in- or outpatients), the effectiveness and tolerability of nimesulide 50 mg/dose were compared with those of lysine-acetylsalicylate 720 mg/dose (equivalent to 200mg of salicylate). Each agent was administered to 35 children, and both groups were simultaneously treated with antibiotics. General and respiratory symptoms were evaluated daily. Nimesulide treatment was associated with a more rapid and greater antipyretic effect than lysine-acetylsalicylate: 94% of nimesulide recipients and 77% of lysine-acetylsalicylate recipients were considered by physicians to have a good or very good response to therapy (p < 0.05). Furthermore, fewer doses of nimesulide than lysine-acetylsalicylate were required for resolution of fever and associated symptoms (nausea, vomiting, headache). The 2 drugs had similar global efficacy. Tolerability was good or very good in all patients. |
| Databáze: |
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