| Autor: |
Moro, Ana Maria, Targino, Roselaine Campos, Oliveira, Erica Aparecida de, Seo, Daniele, Faintuch, Bluma Linkowski |
| Zdroj: |
Current Radiopharmaceuticals; April 2017, Vol. 10 Issue: 1 p65-72, 8p |
| Abstrakt: |
Background and Objective: Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists. Methods: We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium- 99m. Two different sites of the biomolecule were selected for chelator attachment. Results: HYNIC-Ala chelator attached to serine (C- terminus) of exendin, was associated with higher tumor uptake than to aspartate (N- terminus). Conclusion: The chelator position in the biomolecule influenced receptor uptake. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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