Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial

Autor: Williams, Hywel C, Wojnarowska, Fenella, Kirtschig, Gudula, Mason, James, Godec, Thomas R, Schmidt, Enno, Chalmers, Joanne R, Childs, Margaret, Walton, Shernaz, Harman, Karen, Chapman, Anna, Whitham, Diane, Nunn, Andrew J, Adams, J, Akhras, V, Anstey, A, Barnard, C, Bell, H, Blackford, S, Bröcker, E, Carmichael, A, Coelho, R R, Craig, F, Davies, K, Ellis, R, English, J, Gläser, R, Groves, R, Günthert, C, Hampton, P J, Hepburn, N, Hügel, R, Hussain, K, Ingram, J, Layton, A M, Levell, N J, Lewis, V, Malhomme, H, Omerod, A, Patel, G, Rallan, R, Ravenscroft, J, Santander, H, Steinbrink, K, Sticherling, M, Thomas, C, Vatve, M, van Beek, N, Venning, V, Veysey, E, Wachsmuth, R, Wahie, S, Walker, B, Walsh, M, Wee, J, Westmoreland, M, Wong, G, Ferguson, Adam, Verpetinske, Indre, Duarte-Williamson, Emilia, Antony, Fiona, Bower, Chris, Gawkrodger, David, Taghipour, Kathy, Dunnill, M G S, Waters, Alex, Bottomley, Walter, Wright, Andrew, Sterling, Jane, Azam, Adzura, Gibbs, Sam, Luger, Thomas, Salvary, Ingrid, Lovell, Chris, Ilchyshyn, Andrew, Gibbon, Karen, Nik, Marinella, Charles-Holmes, Robert, Lavery, A Lloyd
Zdroj: The Lancet; April 2017, Vol. 389 Issue: 10079 p1630-1638, 9p
Abstrakt: Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over starting treatment with oral corticosteroids.
Databáze: Supplemental Index