| Autor: |
Silva, Marly Conceição, Magalhães, Tiago Augusto, Meira, Zilda Maria Alves, Rassi, Carlos Henrique Reis Esselin, Andrade, Amanda Cristina de Souza, Gutierrez, Paulo Sampaio, Azevedo, Clerio Francisco, Gurgel-Giannetti, Juliana, Vainzof, Mariz, Zatz, Mayana, Kalil-Filho, Roberto, Rochitte, Carlos Eduardo |
| Zdroj: |
JAMA Cardiology; February 2017, Vol. 2 Issue: 2 p190-199, 10p |
| Abstrakt: |
IMPORTANCE: In Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), interventions reducing the progression of myocardial disease could affect survival. OBJECTIVE: To assess the effect of early angiotensin-converting enzyme (ACE) inhibitor therapy in patients with normal left ventricular function on the progression of myocardial fibrosis (MF) identified on cardiovascular magnetic resonance (CMR). DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial conducted in 2 centers included 76 male patients with DMD or BMD undergoing 2 CMR studies with a 2-year interval for ventricular function and MF assessment. In a non–intent-to-treat trial, 42 patients with MF and normal left ventricular ejection fraction (LVEF) were randomized (1:1) to receive or not receive ACE inhibitor therapy. The study was conducted from June 26, 2009, to June 30, 2012. Data analysis was performed from June 30, 2013, to October 3, 2016. INTERVENTIONS: Randomization (1:1) to receive or not receive ACE inhibitor therapy. MAIN OUTCOMES AND MEASURES: Primary outcome was MF progression from baseline to the 2-year CMR study. RESULTS: Of the 76 male patients included in the study, 70 had DMD (92%) and 6 had BMD (8%); mean (SD) age at baseline was 13.1 (4.4) years. Myocardial fibrosis was present in 55 patients (72%) and LV systolic dysfunction was identified in 13 patients (24%). Myocardial fibrosis at baseline was an independent indicator of lower LVEF at follow-up (coefficient [SE], −0.16 [0.07]; P = .03). Among patients with MF and preserved LVEF (42 [55%]), those randomized (21 patients in each arm) to receive ACE inhibitors demonstrated slower MF progression compared with the untreated group (mean [SD] increase of 3.1% [7.4%] vs 10.0% [6.2%] as a percentage of LV mass; P = .001). In multivariate analysis, ACE inhibitor therapy was an independent indicator of decreased MF progression (coefficient [SE], −4.51 [2.11]; P = .04). Patients with MF noted on CMR had a higher probability of cardiovascular events (event rate, 10 of 55 [18.2%] vs 0 of 21 [0%]; log-rank P = .04). CONCLUSIONS AND RELEVANCE: In this 2-year, follow-up, randomized clinical trial of patients with Duchenne or Becker muscular dystrophy whose LVEF was preserved and MF was present as determined on CMR, ACE inhibitor therapy was associated with significantly slower progression of MF. The presence of MF was associated with worse patient prognosis. TRIAL REGISTRATION: clinicaltrials.org Identifier: NCT02432885 |
| Databáze: |
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