| Autor: |
Kodama, Mitsuo, Kodama, Toshiko, Totani, Ryozo |
| Zdroj: |
American Journal of Obstetrics and Gynecology; October 1981, Vol. 141 Issue: 3 p288-293, 6p |
| Abstrakt: |
Dissociation between hydatidiform mole (HM) and chorioadenoma destruens, (CA) was attempted by gas chromatographic analysis of urinary steroids, In the chromatogram, fraction 2 (F2) including four pregnane steroids (17-hydroxypregnanolone, pregnanolone, pregnanediol, and pregnanetriol) reflected the biologic activity of molar human chorionic gonadotropin (hCG), and the ratio of F2to fraction 1 (F1) (17-ketosteraids) was found useful in monitoring secondary growth of trophoblastic tumor: Urinary log F2/F1after curettaga declined quickly and unidirectionally in HM, but the same parameter exhibited a temporal rise in CA at 11 to 20 days after curettage because of the molar hCG from residual tumor tissue. The resolution between HM and CA at that stage (11 to 20 curettage days) was of the order of diagnostic use and superior to that with immunoreacive hCG. The data obtained are discussed in the light of pathophysiology of CA. |
| Databáze: |
Supplemental Index |
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