| Autor: |
Rashid, M. A., Cantrell, C. L., Gustafson, K. R., Boyd, M. R. |
| Zdroj: |
Journal of Natural Products; October 26, 2001, Vol. 64 Issue: 10 p1341-1344, 4p |
| Abstrakt: |
Chondropsin D (2), a new 37-membered-ring macrolide lactam, was isolated as a minor constituent of an aqueous extract of the marine sponge Chondropsis sp. This sponge sample had previously been the source of chondropsins A (1) and B, two novel polyketide-derived macrolides with potent cytotoxic activity. The structure of 2 was initially deduced from analysis of spectral data. This assignment was supported by the observation that chondropsin A (1), which contains a 35-membered macrocyclic ring, could be converted to chondropsin D (2) by a base-catalyzed intramolecular transesterification reaction. Rearrangement of the methylated derivative of chondropsin A (3) to the corresponding methylated analogue of chondropsin D (4) confirmed the structure of 2. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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