| Autor: |
Klunda, Tomáš, Machová, Eva, Čížzová, Alžzbeta, Horák, Radim, Poláková, Monika, Bystrický, Slavomír |
| Zdroj: |
Chemical Papers; September 2016, Vol. 70 Issue: 9 p1166-1170, 5p |
| Abstrakt: |
Candidainfections are becoming increasingly prevalent and many clinical isolates are resistant to common azole derivatives treatment. Accordingly, the capacity of a series of 19 alkyl glycosides, mainly mannosides and glucosides but also a cellobioside with aglycone chain-length from C-6 to C-20, to inhibit the growth of laboratory and clinically isolated strains of Candida albicans, was investigated. The study showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida, strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink