| Autor: |
Kuhn, Louise, Coutsoudis, Anna, Moodley, Derseree, Mngqundaniso, Nolwandle, Trabattoni, Daria, Shearer, Gene M, Clerici, Mario, Coovadia, Hoosen M |
| Zdroj: |
Pediatric Research; September 2001, Vol. 50 Issue: 3 p412-416, 5p |
| Abstrakt: |
Immunologic consequences of exposure to HIV-1 in utero are still poorly understood. This study investigates relationships between type-1 [interferon-? (IFN-?)] and type-2 (IL-10) cytokine production and maternal-infant HIV-1 transmission. Cord blood leukocytes from deliveries of 71 HIV-1–infected and 11 uninfected mothers were tested for in vitro IFN-? and IL-10 production after phytohemagglutinin (PHA) stimulation. The infants of these HIV-1–infected mothers were followed prospectively after birth to determine HIV vertical transmission, and IFN-? and IL-10 production was measured again at 6 mo. Median PHA-stimulated IFN-? production was 210 pg/mL in cord blood cells from infected and 73 pg/mL from uninfected mothers (p = 0.12), and median PHA-stimulated IL-10 production was 491 pg/mL in cord blood cells from infected and 161 pg/mL from uninfected mothers (p = 0.004). PHA-stimulated IFN-? and IL-10 production alone were not significantly associated with transmission, but relationships between the two cytokines differed among infected and uninfected infants of HIV-1–infected mothers. PHA-stimulated IFN-? and IL-10 production was positively correlated among infected (r = 0.7, p = 0.12 in cord blood and r = 0.66, p = 0.03 at 6 mo) but not uninfected infants, and stronger relative production of IFN-? to IL-10 was observed among exposed uninfected than among infected infants (p = 0.04). Exposure in utero to HIV-1 may augment production of IL-10 detectable in fetal cord blood. Stronger relative production of IFN-? to IL-10 in cord blood cells from infants of HIV-1–infected mothers may be associated with protection against perinatal HIV infection. |
| Databáze: |
Supplemental Index |
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