| Autor: |
Jones, Rosamond A, Wincott, Elizabeth, Elbourne, Diana, Grant, Adrian, McIntosh, Neil |
| Zdroj: |
Pediatric Research; February 1994, Vol. 35 Issue: 2 p274-274, 1p |
| Abstrakt: |
287 preterm babies from 31 European and North American centres who were oxygen-dependent aged 3 weeks or more were randomized to dexamethasone or placebo. Active treatment was associated with reduced time on assisted ventilation and no observed increase in Berious immediate side-effects. 62 infants died. Survivors were followed up at 3 years of age, using questionnaires to GPs, health visitors and parents. Data are available for 209 infants (93% of survivors and 100% of UK residents).Despite early benefits, there were no clear effects on respiratory morbidity, rates of infection, or overall disability. An J9 of the placebo group later received open steroids, even a trial of this size would have limited statistical power to detect a moderate effect on these adverse outcomes. Irrespective of random allocation, overall morbidity was high. A trial of prophylactic dexamethasone is planned. |
| Databáze: |
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