| Autor: |
Conley, Susan B, Rose, Gilbert M, Bier, Dennis M |
| Zdroj: |
Pediatric Research; April 1978, Vol. 12 Issue: 1, Number 1 Supplement 4 p539-539, 1p |
| Abstrakt: |
Growth failure remains a concern in children on chronic hemodialysis. Inadequate intake of protein and calories is one cause. However little is known about the dynamic aspects of protein metabolism in these children. We investigated this by measuring whole body protein turnover from lysine-15N enrichment during 14 hr infusions of 15N labelled lysine, using newly developed gas chromatography-mass spectrometry micromethods. The patients had been on dialysis for 11.7 ± 10.7 months. All were below the 10th percentile for ht and wt. Prior to dialysis when BUN averaged 64.3 ± 38.8 mg/d1 and serum creatinine 9.7 ± 5.4 mg/d1, the mean protein turnover rate was 2.36 ± .34 gm protein/kg body wt/day, a value significantly below the normal of 3.8. Protein turnover was reduced even in children ingesting 2 gm protein/kg body wt/day. To determine whether decreasing the degree of azotemia would improve protein turnover rates, studies were repeated after dialysis (average BUN 23.0 ± 15.7, serum creatinine 4.2 ± 2.6 mg/d1). Protein turnover remained identical 2.36 ± .33 gm protein/kg body wt/day. This study illustrates that even with adequate dietary protein intake, children on he-modialysis have decreased protein turnover. This is not improved by dialysis. Identification of the mechanisms responsible for this decrease should help the development of methods to increase growth rates in uremic children. |
| Databáze: |
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