| Autor: |
Hughes, Walter, Kuhn, Shirley, Chaudhary, Subhash, Feldman, Sandor, Verzosa, Manuel, Aur, Rhomes, Pratt, Charles |
| Zdroj: |
Pediatric Research; April 1977, Vol. 11 Issue: 4 p501-501, 1p |
| Abstrakt: |
After demonstrating in animal studies that trimethoprim-sulfamethoxazole (TMP-SMZ) administered prophylactically prevented PCP, a double-blind, placebo-controlled study was done in children with cancer at high risk for PCP. A group of 160 children with an expected attack rate of 20% for PCP, were randomized to receive TMP-SMZ or a placebo from Oct. 1974 to Oct. 1976.PCP occurred in 17/80 (21%) of the placebo group and none of the 80 patients receiving TMP-SMZ. The occurrences of certain other infections in the two groups are tabulated:Serial bacterial and fungal cultures of the pharynx and rectum, tests for renal and liver function and serum folate determinations revealed no adverse effects from TMP-SMZ prophylaxis. The course of the malignancies was not affected. TMP-SMZ prophylaxis is an effective approach to the prevention of PCP as well as certain other infections and, with the exception of oral candidiasis, is not associated with significant adverse effects. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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