| Autor: |
Lopes Cardozo, Robbert H, De Beaufort, Arnout Jan, Geesink, Beerthe J, Benders, Manon J N L, Moison, Ralf M W, Van De Bor, Margot, Berger, Howard M, Van Bel, Frank |
| Zdroj: |
Pediatric Research; July 1994, Vol. 36 Issue: 1 p25A-25A, 1p |
| Abstrakt: |
Ventilation with NO is increasingly being used to treat pulmonary hypertension in the newborn. In the brain NO is involved in neurotransmission and has vasoactive properties. However, the effect of inhaled NO on cerebral function and blood flow is not known. Furthermore, there is little information on the peroxidative complications by use of this free radical gas.We investigated the effect of inhaled NO (1-60 ppm) in 6 ventilated newborn lambs before and after group B streptococci (GBS) induced pulmonary hypertension. Blood pressure in the pulmonary artery (Pap) and aorta (PAo), cerebral blood flow (CBF, ultrasonic-determined carotid flow) and cerebral electrical activity (CEA using a cerebral function monitor) were measured. Blood gases, indices of antioxidant status (vitamin C, MDA and glutathione) and methemoglobin were determined in blood samples from the left ventricle. With inhalation of NO before and after GBS induced pulmonary hypertension a decrease of the Pap(16?11 mmHg and 27?12 mmHg resp) and an increase of the paO2(13?18 kPa and 10?17 kPa resp) was observed. CBF (65-80 mL/min), CEA (25-45 muV) and indices of antioxidant status were in the normal range and did not change significantly. Methemoglobin was not detected.Inhalation of NO (up to 60 ppm) lowered Pap, without having an effect on CBF, CEA, and antioxidant status in the pulmonary vessels. |
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