| Autor: |
Leung, Donald Y M, Sullivan, Kathleen E, Brown-Whitehorn, Terri F, Fehringer, Amy P, Allen, Steven, Finkel, Terri H, Washington, Reginald L, Makida, Ryuji, Schlievert, Patrick M |
| Zdroj: |
Pediatric Research; September 1997, Vol. 42 Issue: 3 p268-272, 5p |
| Abstrakt: |
Kawasaki syndrome (KS) has been reported to be associated with selective expansion of Vß2+T cells and either staphylococcal toxic shock syndrome toxin-1 or streptococcal pyrogenic exotoxin C in uncomplicated cases. However, there have been no previous studies on the role of superantigens in KS associated with coronary artery disease, the major complication of this illness. The present study characterized bacteria isolated from three acute KS patients who developed coronary artery disease. Staphylococcus aureus secreting either TSST-1 (n = 3) or exfoliative toxin A(n = 1), both known to stimulate expansion of Vß2+T cells, were isolated from all three patients. The percent Vß2+T cells was determined in three patients with coronary artery disease. On presentation, one patient demonstrated reduction, whereas the other two showed expansion, of Vß2+T cells. Repeat analyses of the latter two children showed their percent Vß2+T cells to decrease toward normal. These observations suggest that coronary artery disease in KS may result from superantigenic stimulation of Vß2+T cells. This is also the first demonstration of an association of staphylococcal exfoliative toxin with acute KS. The observation that three different bacterial toxins associated with KS are potent activators of Vß2+T cells suggests an important role for this T cell subset in the pathogenesis of this autoimmune disease. |
| Databáze: |
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