| Autor: |
Kosmidis, Helen V, Shope, Thomas, Dajani, Adnan, Ravindranath, Y, Lusher, Jeanne |
| Zdroj: |
Pediatric Research; April 1978, Vol. 12 Issue: 1, Number 1 Supplement 4 p467-467, 1p |
| Abstrakt: |
A 20-month prospective study was undertaken to determine the role of bacterial and viral infections as a cause of fever in children with acute leukemia (AL) and to determine if respiratory and gastrointestinal colonization could predict subsequent bacterial infection. 47 children with newly diagnosed AL had viral and bacterial cultures and serum obtained at the time of diagnosis, during febrile episodes and at the time of periodic clinic visits while asymptomatic and afebrile. 72 febrile episodes were documented. (27 during the initial induction phase and 45 subsequently.) A cause for the fever was found on 31 occasions and among those 15 bacterial and 9 viral agents were isolated. In 7 others with pneumonia or otitis media no etiologic agent was found. Of the 31 episodes of documented infections, 20 occurred during induction or relapse, and 11 while in remission.Colonization of the upper respiratory or gastrointestinal tract with the infectious agents was documented prior to the infection in only 4 of the 15 bacterial infections.It is concluded that (1) viruses as well as bacteria are significant infectious agents in children with AL and (2) the bacterial infections were predictable in 4 of the 15 cases by periodic determinations of the flora during afebrile periods. In this series no deaths occurred as the result of viral infection alone, while 6 of the 11 children with bacterial sepsis expired. |
| Databáze: |
Supplemental Index |
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