| Autor: |
Halpin, T C, Izant, R J, Behrman, R E |
| Zdroj: |
Pediatric Research; April 1978, Vol. 12 Issue: 1, Number 1 Supplement 4 p435-435, 1p |
| Abstrakt: |
The etiology of HD remains unknown and can be confused with other NIOS. Rectal biopsy has traditionally established the diagnosis of HD. In the present investigation, rectal tissue was obtained with multipurpose suction tube at 1-2 cm above the mucocutaneous junction. Proctosigmoidoscopy was normal in all cases. In addition, rectal tissue was placed into organ culture for 24 hr. A single phase antibody radioimmunoassay was used to determine IgG, IgM & IgA levels in homogenized cultured rectal tissue (H) and its secretions (S). Results are expressed as µg of immunoglobulin/mg tissue protein. HD & NIOS have been compared to an older control group of children with Functional Abdominal Pain.For HD, an increase of IgG in both homogenate and secretions was noted compared to controls (p<0.005) and NIOS (p<0.005). Results suggest there is either increased tissue synthesis of IgG or transfer of serum maternal IgG. The explanation of the observed increased IgG in rectal tissue of children with HD is unknown |
| Databáze: |
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