| Autor: |
Sanderud, Jon, Saugstad, Ola D |
| Zdroj: |
Pediatric Research; December 1991, Vol. 30 Issue: 6 p657-657, 1p |
| Abstrakt: |
The plasma kallikrein-kinin system is activated during trauma and shock, and oxygen radical generating systems may be involved in such activation. To study the effects of the HX-XO system, plasma prekallikrein (PK) and kallikrein inhibition (KKI) values were measured together with kallikrein (KK) activity by a chromogenic substrate (S-2302) in five groups of young pigs.1) Pigs given XO as a bolus dose 1 U/kg into the right atrium.2) Pigs infused with HX (10 mmol/l) before XO. 3) Pigs given allopurinol 50 mg/kg before XO. 4) Pigs given catalase (25.000 U/kg) and XO. 5) Pigs pretreated with indomethacin (7.5 mg/kg) before XO. The table shows mean (SD) relative changes from baseline levels 130 minutes after XO infusion.The data indicate that xanthine oxidase does not activate the kallikrein-kinin system during this short observation time. |
| Databáze: |
Supplemental Index |
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