| Autor: |
von Planta, Maya, Ritter, Mary, Batchelor, Ritchard |
| Zdroj: |
Pediatric Research; December 1991, Vol. 30 Issue: 6 p628-628, 1p |
| Abstrakt: |
5-10 % of HLA identical, living related Kidney grafts are lost due to immunological rejection revealing the importance of non-HLA-antigens in transplantation. The observation that mixed lymphocyte culture inhibiting antibodies do not inhibit mixed lymphocyte endothelial cell culture responses pinpointed alloantigens on endothelial cells. 41 sera without detectable HLA antibodies from patients with rejected renal allografts and 29 sera of highly sensitized subjects with HLA antibodies were screened for the presence of anti-endothelial cell antibodies. A double immunofluorescence technique was applied after blocking HLA class I antigens. Anti-endothelial cell reactivity was demonstrated in 7 % of sera from unsensitized and 76 % of sera from highly HLA-sensitized patients. Successive serum samples of one unsensitized patient contained anti-endothelial cell antibodies before and six months after transplantation. Conclusion: We identified anti-endothelial cell antibodies to a non-HLA-antigen system in sera from unsensitized and highly sensitized patients with rejected kidney allografts. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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