| Autor: |
Faden, Howard, Hong, Jung J, Krystofik, Deborah, Bernstein, Joel, Stanievich, John, Brodsky, Linda, Ogra, Pearay L |
| Zdroj: |
Pediatric Research; April 1987, Vol. 21 Issue: 4 p324A-324A, 1p |
| Abstrakt: |
The antibody response to nontypable Haemophilus influenzae (NTHI) was determined in the normal population and in children with otitis media by an immunodot assay. Preliminary studies confirmed the specificity and IgG nature of the antibody measured. The mean antibody titers for individuals in various age groups were as follows: newborn 25,600; 0.5 years (y) 3,200; 1 y 6,400; 1.5 y 6,400; 2 y 6,400; 4 y 25,600; 6 y 25,600; 10 y 25,600; adult 25,600, a serologic pattern remarkably similar to infection with Haemophilus type B. The antibody response in the systemic circulation of young children with otitis media reflected the titer of the corresponding normal age group. In contrast, the level of antibody in the middle ear fluid reflected prior exposure to NTHI. For example, the antibody titer in the middle ear fluid during the first episode of otitis media with NTHI was negligible (< 25). During the second episode, the antibody titer rose to approximately 100 in the middle ear fluid of the infected ear while the titer in the noninvolved ear remained low. Recurrent otitis media resulted in very high titers of antibody in the middle ear fluid (1600) while simultaneous systemic antibody levels continued to reflect age-specific normal values. These data suggest that children do not produce significant systemic antibody to NTHI until four years of age. However, local antibody production in the middle ear mirrors prior sensitization to NTHI. |
| Databáze: |
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