| Autor: |
Black-Payne, Cynthia, Ahrabi, Mitra M, Bocchini, Joseph A, Brouillette, Rose M, Ridenour, Carol R, Herbst, J J |
| Zdroj: |
Pediatric Research; April 1987, Vol. 21 Issue: 4 p322A-322A, 1p |
| Abstrakt: |
Ct colonization of the endocervix is common during pregnancy and infants are frequently infected during delivery. Recent data indicates that treatment will reduce perinatal transmission. CZ (Abbott Lab.) is a rapid, accurate enzyme immunoassay for Ct antigen detection which allows definitive diagnosis in an economic manner. We prospectively evaluated 200 asymptomatic women in the third trimester (EGA 28-32 weeks). An endocervical specimen from each woman was submitted for CZ. 52/200 (26%) were positive and offered treatment with erythromycin. Sexual partners were also treated. CZ was repeated 3-4 weeks after therapy in 38/52 (73%) positive women and only one (3%) remained positive. To date, 34/52 (65%) infants born to positive women have been prospectively evaluated for upper respiratory infection (URI), pneumonia (P), otitis media (OM), and conjunctivitis (C). Infants of 30 CZ negative women served as controls. The results are as follows:We conclude that CZ is a useful means of identifying Ct colonization during pregnancy and that treating CZ positive women with erythromycin reduces the incidence of chlamydia-like illness in their infants to that of infants born to uncolonized women. |
| Databáze: |
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