| Autor: |
Bökkerink, Jos P M, De Abreu, Ronney A, Van Laarhoven, Jan P R M, Bakker, Marinka A H, Hulscher, Tilly W, Schretlon, Egbert D A M, De Bruyn, Chris H M M |
| Zdroj: |
Pediatric Research; July 1985, Vol. 19 Issue: 7 p746-746, 1p |
| Abstrakt: |
Cell growth of Molt-4 cells was hardly influenced by a 24 hrs incubation with 6-mercaptopurine (6MP) concentrations under 5 µM or by a 24 hrs incubation with 0.002 µM methotrexate (MTX). After a 24 hrs incubation with 0.02 µM MTX the cell growth was inhibited partially and with 0.2 µM MTX the cell growth was inhibited completely.In experiments, where the cells were incubated for 24 hrs with 2 µM 6MP after 24 hrs preincubation with 0.02 µM MTX, a greater inhibition of cell growth was obtained than in experiments with 0.02 µM MTX alone.In experiments, where 2 µM 6MP and 0.02 µM MTX were added simultaneously to the cells or 6MP was added 24 hrs prior to MTX inhibition, no synergy was observed.The results of the experiments on soft-agar clonogenicity of the Molt-4 cells, were found comparible to those of cell growth. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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