| Autor: |
Mumford, David M, Sung, Joyce S, Wallis, J Owens, Kaufman, Raymond H |
| Zdroj: |
Pediatric Research; March 1978, Vol. 12 Issue: 3 p171-175, 5p |
| Abstrakt: |
Summary: Lymphocyte transformation responses to three different mitogens (phytohemagglutinin (PHA), pokeweed mitogen (PWM), and concanavalin A (Con A)) as well as four antigens (streptolysin O (SLO), keyhole limpet hemocyanin (KLH), streptokinase-streptodornase (SKSD) and tuberculin purified protein derivative (PPD)) were studied ontogenetically in 30 human fetuses ranging in gestational age from 6–19 weeks.In most organs lymphocyte responsiveness to Con A in human fetuses seemingly develops in concert with responsiveness to PHA and PWM. One 19 week fetus had an apparent antigen specific response to SLO with stimulation of cord blood and bone marrow lymphocytes. The same fetus also had mitogen responsiveness in bone marrow.Speculation: The onset of response to different mitogens (PHA, PWM, and Con A) apparently fails to distinguish subpopulations of lymphocytes in most fetal organs tested. Such agents may be of restricted value in studies of early immune ontogeny. Observation of one case of apparent fetal sensitization to SLO at 19 weeks gestational age suggests that transplacental immunization without gross infection may not be as rare as is believed currently. |
| Databáze: |
Supplemental Index |
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