| Abstrakt: |
Toxicity to neonates from drug solvents is of concern. We reported serum hyperosmolarity due to Propylene Glycol (PG) in MVI-12. This study compared two groups of infants weighing < 1500 grams. Gr PG-received MVI-Conc. (with PG) 1 cc/d in their PN and Vit. E 50 u/wk IM. Gr Mann.-received MVI-Ped. (with Mannitol) 6.5 cc/d. Serum & urine osm. PG levels, BUN, creatinine, Na & glucose were measured days 0,2, 5, 12, 19, 26, 33 & 40 on PN. Weight, urine output, and fluid intake were measured daily. Vit E levels were measured on days 5, 26 & 33 on Pn. Mannitol levels were not measured. RESULTS: There were no differences between the groups in birth weight, gest. age, sex or age & wt. at start of PN. PG < 1000gm-serum mosm. correlated with serum PG during first 12 days of PN. (PG levels 2.4-108.4 mg/dl.) 14.2% of serum osmol. values were > 310mosmol/L. Mann, gr. < 1000gm-12.6% serum mosm. were > 310mosmol/L. No diuretic effect of Mannitol was detected. MVI-Ped. in recommended doses may produce higher than desirable vit. E levels. |
