| Autor: |
Bell, Alan, Kennaugh, Jan M, Battaglia, Frederick, Makowski, Edgar L, Meschia, Giacomo |
| Zdroj: |
Pediatric Research; April 1985, Vol. 19 Issue: 4 p150A-150A, 1p |
| Abstrakt: |
Previous studies of fetal metabolism were confined to the last 20% of gestation. This report presents data on 11 fetal lambs chronically catheterized at 71-81 days (mid-gestation). Mean fetal weight was 210 ± 20 g. Umbilical and uterine blood flows, and the AV differences of substrates were determined. Oxygen (VO2) glucose (G.U.) and lactate (L.U.) uptakes by the fetus were calculated. VO2was slightly higher (%) on a wet weight basis than at term. But this represented a 250% increase expressed on a dry weight basis. Fetal G.U. was also increased relative to the term fetus but L.U. was decreased.At mid-gestation placental weight is significantly greater than at term (486 ± 22 vs 302 ± 12 g). Nevertheless, the rates of placental oxygen and glucose metabolism were significantly less than in late pregnancy and placental lactate production was also reduced. Developmental aspects of fetal metabolism and physiology can now be studied under unstressed steady-state conditions. |
| Databáze: |
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