| Autor: |
Ward, Robert M, Wood, Mary Ann, Donahue, Margaret L, L, Jeanne, Jeffrey Maisels, Addison M |
| Zdroj: |
Pediatric Research; April 1985, Vol. 19 Issue: 4 p181A-181A, 1p |
| Abstrakt: |
T therapy of neonates has been associated with oliguria and renal failure which has not been studied thoroughly. We have reported T dosing in lambs to rapidly reach steady state (SS) plasma T concentrations. This study evaluated the effects of T at SS upon urine output (UO) and the cardiovascular (CV) system in chronically catheterized, resting lambs. Similar 6-7 hour experiments were conducted on separate days in the same lambs receiving either control saline (C) (n=5) or T (n=6) infusions. Experiments included study periods: 1=control; 2=reach T SS; 3, 4, 5=hourly studies at T SS; 6=T SS + double fluid intake. Fluid intake was constant at 15.9±2.5ml/kg/hr during study periods 1-5 and not different between all C and T study periods. During C study periods 1-5, UO was constant at 3.34±0.51 (mean ±SD) ml/kg/hr and increased to 10.65±2.46ml/kg/hr during period 6. CV parameters did not change during C, although volume expansion in period 6 increased CI 30% (p=0.51). During T infusion, UO decreased from 3.04±0.86 to 0.61ml/kg/hr (p<.03) and returned to 1.01±0.39ml/kg/hr by three hours. Volume expansion at 33.9±5.9ml/kg/hr increased UO only to 48% of control. When compared to C, T produced the following CV changes: ↑ heart rate (p<.01); ↑ cardiac index (p<.05); ↓ aortic pressure (p<.05); ↓ systemic vascular resistance (p<.02). These results indicate T initially inhibits its own elimination, possibly by dilating peripheral vasculature and diverting blood flow from the kidneys. Although volume expansion increased UO, it did not return to the control rates before beginning T infusion. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
