| Autor: |
Merritt, T Allen, Swensson, Richard E, Talner, Norman S, Sahn, David J |
| Zdroj: |
Pediatric Research; April 1985, Vol. 19 Issue: 4 p354A-354A, 1p |
| Abstrakt: |
To determine whether the early improvement in very preterm infants with severe RDS receiving human surfactant (HS) treatment was related to decrease in ductal left-to-right shunting, we studied 9 infants treated with HS within 6 hours after birth (B.W. x 957 Gm.; G.A. x 27 wks.) and compared them to 11 controls (B.W. x 1038 Gm.; G.A. 27.2 wks.). All 9 HS treated infants showed marked left-to-right PDA shunting when studied with 2D echo/Doppler prior to, 1-4 hours after HS. Control infants were also studied at comparable times and all demonstrated ductal flow by 10 hours after birth. Infants were then treated with IV indomethacin. There was a decrease in ductal flow in all infants receiving HS at 6-12 hours with 7/8 HS-treated patients having evidence of ductal closure (no reverse flow in the pulmonary artery and no PDA seen) at 18-24 hours after HS. All control infants continued to demonstrate some evidence of ductal shunting until the second day with ductal closure occurring in 7/11. Thus early treatment of RDS with HS appears to augment response of the ductus to indomethacin in very small preterm infants with severe RDS, and may be contributory to their ventilatory improvement. (HD 16292) |
| Databáze: |
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