| Abstrakt: |
Limited information is available regarding the developmental outcome of survivors of PPH.Of 36 infants admitted with PPH in 1979-1982, 26 survived. Twenty-one were evaluated at 4, 8 and 12 mos. of age by physical exam, neuromuscular testing and Bayley Scales of Infant Development. The mean MDI was 106±18.9(median 102) and mean PDI was 90.8±18.1(median 91). Ten infants were normal (47.6%) and 11 infants (52%) had mild to severe developmental abnormalities. Of the abnormal infants 7(33%) had an MDI and/or PDI 1 S.D. below the mean and a mild neuromuscular abnormality. Four(19%) had an MDI and/or PDI 2 S.D. below the mean and/or severe neuromuscular deficit. Two infants had chronic lung disease and growth failure. In review of neonatal data on the normal and abnormal infants, there was no difference in birthweight, race, sex, number inborn, lowest paO2and pH, highest paO2, pCO2and pH. However the abnormal infants spent a significantly greater number of hours with pCO2<25 than the normal infants, 120±62 vs 60±73. (p<.01).This result is in variance with previous reports of generally good developmental outcome in infants made hypocapneic during PPH and suggests that caution in applying hyperventilation is warranted until further data are available. |
