| Autor: |
Sann, Léon, Bienvenu, Franpise, Bienvenu, Jacques, Philip, Alistair G S |
| Zdroj: |
Pediatric Research; April 1984, Vol. 18 Issue: 1, Number 1 Supplement 4 p285A-285A, 1p |
| Abstrakt: |
AGP (orosomucoid) and CRP provide help in the diagnosis of bacterial infection in neonates. Their use in following the course of systemic neonatal infection was evaluated in 49 neonates (GA:mean35 weeks,range 26-41w;BW:mean2206g.,range 880-4400) using sequential, quantitative (nephelometric) determinations. Early infection (<6 days of age) was observed in 28 patients:late in 21 patients. The outcome was favorable in all but 8 infants. Initial AGP and CRP concentrations were (mean ± 1SD)133 ± 75 mg/dl and 8.4 ± 7.5 mg/dl. After 5-6 days of favorable evolution, CRP decreased to a mean of 4.7 mg/dl (< 0.5-17.5) and after 13-16 days to 2.0 mg/dl (<0.5-18.8). Serum AGP increased to 142 ± 73 mg/dl and then decreased to 116 ± 75 mg/dl after the same time intervals. Higher values were associated with meningitis. During the 3rd week, no CRP value was above 0.8 mg/dl, and AGP was normal at 86 ± 40 mg/dl. The normalization of serum AGP was similar to clinical healing.In contrast, a dramatic increase of CRP was observed in patients with a bad outcome, especially 3 patients who died and two with profound neurologic damage. In one patient with arthritis the recurrence of symptoms was observed with a re-elevation of serum AGP while serum CRP was normal. The data confirm the abnormal elevation of serum CRP and AGP in neonates with bacterial infection. They suggest that CRP is a reflection of the efficacy of the treatment and that the normallization of serum AGP coincides with recovery. |
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