| Autor: |
Wang, Jaw J, Hananian, Juliet, Sinks, Lucius F |
| Zdroj: |
Pediatric Research; April 1974, Vol. 8 Issue: 4 p410-410, 1p |
| Abstrakt: |
Children who have cancer or leukemia usually have an abbreviated life span in which another tumor could manifest itself as compared to an adult population. This study includes a survey of children with leukemia or cancer below 16 years of age seen from June 1946 to December 1971 at RPMI. Sixteen of 884 cases (1.8%) showed the presence of a second primary tumor (SPT). There were 12 malignant and 4 benign lesions. Among 371 cases of acute leukemia, only 1 SPT was found. Three cases of SPT, including one each of Hodgkin's Disease, fibrosarcoma and osteosarcoma were observed in retinoblastoma patients. Among 41 cases of Wilm's Tumor, 2 SPT, including one chondrosarcoma and one osteochondroma were found. One patient with Hodgkin's Disease and chronic myelocytic leukemia had Positive Philadelphia Chromosome. One patient with xerodermia developed both squamous cell carcinoma and malignant melanoma. Two children with glioblastoma multiforme and rhabdomyosarcoma developed hepatoblastoma. A neuro-astrocytoma was observed in one child with acute leukemia and in one with adenocarcinoma of the colon. One child, who was cured of glioblastoma multiforme, developed reticulum cell sarcoma. In 7 children the SPT were detected at the time of diagnosis of the primary malignancy. In 4 cases the SPT occurred 2.5-16 years after radiotherapy and were possibly radiation induced. |
| Databáze: |
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