| Autor: |
Tucker, Charles R, Johnson, David H, Rosenthal, Amnon, Williams, Roberta G, Khaw, Kon Taik, Shwachman, Harry |
| Zdroj: |
Pediatric Research; April 1974, Vol. 8 Issue: 4 p355-355, 1p |
| Abstrakt: |
To evaluate the possibility of left ventricular(LV)dysfunction in patients(pts) with cystic fibrosis(CF), we studied 80 ambulatory and hospitalized CF pts with a mean Shwachman-Kulczyki clinical score of 55(range 15-100)using standard pulmonary function tests, echocardiography (ECHO) and systolic time intervals (STI). ECHO measurements were made of LV internal dimensions at end-diastole(ED) and end-systole, LV posterior wall thickness(PWT) and septal thickness(ST). All values were indexed by body surface area. LV-ED volume (LVEDV) and LV ejection fraction(EF) were calculated. We observed an increase in PWT which was directly related to a decrease in clinical score(p<.0l) and mid-maximal expiratory flow rate (p< .05) and increased functional residual capacity (FRC)(p<.05). EF decreased significantly with increased FFC(p<.05). LV-EDV decreased with increased residual volume (RV)(p<.05) and total lung capacity(p<.05). When compared with age-corrected normal values, the ratio of the STI's, pre-ejection period and LV ejection time(PEP/LVET) increased with decreased clinical score(p<.05) and increased RV(p<.01) and FRC(p<.05). PEP/LVET also increased with increased PWT(p<.001), ST(p<.01) and indexed right ventricular dimension by ECHO(p<.001) and with decreased LVEDV(p<.05). These data showing increased PWT and PEP/LVET, and decreased EF suggest LV dysfunction with increasing severity of pulmonary involvement in pts with CF. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
