| Autor: |
Saenger, P, Louis, Y St, Wu, R, Dimartino-Nardi, J, Breidbart, S, Thorpy, M, Sherman, B, Sobel, E |
| Zdroj: |
Pediatric Research; October 1988, Vol. 24 Issue: 4 p533-533, 1p |
| Abstrakt: |
Twenty four hour secretory profiles of growth hormone were measured in 3 children with idiopathic short stature before and 48 hours after 6 months of treatment with rhGH. The study was undertaken to assess the possibility that exogenous GH might impair endogenous secretion. The children were all prepubertal(mean age 10.5yr±.8), with GH levels greater than 10 ng/ml on provocative testing. Growth velocity during therapy increased from a mean of 3.8±1.5 to 7.0±1.5cm/yr, (p<0.001). The repeat studies were carried out under identical conditions in the sleep laboratory. Totalsleep time verified by sleep polysomnography and EEC recordings was identical in both studies (mean 503 vs 505 minutes). Comparison of pre and post treatment GH secretory profiles showed no attenuatiot of endogenous GH levels. Between pulses GH concentration was undectable in the pre and post rhGH treatment study.We conclude that exogenous therapy does not interfere with maintenance of endogenous pulsatile secretion of GH. These data provide evidence, for the resilience of the GH secretory system in the growing child. |
| Databáze: |
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