| Autor: |
Rolf, L H, Ullrich, K, Kurlemann, G, Nieder, U, Huynh, P |
| Zdroj: |
Pediatric Research; August 1987, Vol. 22 Issue: 2 p238-238, 1p |
| Abstrakt: |
Phe was significantly increased (p<0,025) aad Tyr decreased (p<0,05) in platelets (pl.) from patients with PKU as compared to that of controls (2 - 14 years; HPLC-method). No correlation-was found to serum Phe/Tyr content. Amino acids calculated to pmol/108platelets:The in vitro uptake of 3H-Phe and 3H-Tyr by platelets showed saturation kinetics. The uptake of 3H-Tyr was not influenced by platelet Phe content. The relative release of 3H-Tyr from preincubated platelets was the same in the PKU and control group. The values of maximal 3H-Phe-and 3H-Tyr-uptake in PKU patients and controls were as followed (calculated to pmol amino acid/108platelets):Our data indicate that the amino acid transport of Tyr into platelets o children with PKU is reduced. The reduced concentrations of dopa/dopamine in the CSF of these patients aay be partially the result of an intracellular lack of the precursor tyrosine. |
| Databáze: |
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