| Autor: |
Jakacki, R I, Kelch, R P, Sauder, S E, Lloyd, J S, Hopwood, N J, Marshall, J C |
| Zdroj: |
Pediatric Research; December 1981, Vol. 15 Issue: 12 p1539-1539, 1p |
| Abstrakt: |
Pulsatile secretion of LH has not been demonstrated previously in children with a bone age (BA) of <9 yrs. To determine the gonadotropin secretory pattern during childhood, 16 prepubertal children were studied in the CRC. Ten children (Group A) had BA's 4.5-9.5 yrs. ([xmacr ]=7.5y) and six children (Group B) had BA's of 10-11.5y ([xmacr ]=10.3y). Six patients were endocrinologically normal, 9 had isolated growth hormone deficiency and 1 had gonadal dysgenesis. Blood samples were obtained every 20 min. between 1000-1800h and 2200-0600h. LH and FSH were measured by RIA ([xmacr ] sensitivities: LH 0.65; FSH 1.1 mIU/ml). Mean nocturnal LH and FSH values were significantly greater than daytime means in 6/10 & 3/10 Group A children, respectively; in Group B, 4/6 & 1/6 children had augmented [xmacr ] LH and FSH values during the night. Five Group A (youngest BA=4.5y) and 3 Group B children had significant LH pulses during sleep; four Group A and 2 Group B children had LH pulses during the day. In children with discernible LH pulses, frequency was similar between groups at night (Group A 1.7 pulses/4 hr; Group B 1.8 pulses/4 hr), but apparently greater in Group B during the day (A 1.2 pulses/4h; B 2.3 pulses/4h). Nocturnal pulse amplitude was also greater in Group B than in A (A 1.9±0.2; B 2.5±0.3 mIU/ml). These data demonstrate that pulsatile secretion of LH occurs in some children well before a BA of 9y. Furthermore, LH pulse frequency in prepubertal children is similar to that previously reported by us in early pubertal children. Grants HD12306, HD13111, and 5M01RR42 |
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