| Abstrakt: |
The ability of the developing kidney to compensate for a reduction in functioning nephron mass and changes in GT balance following nephron loss were studied in puppies uninephrectomized at birth and in paired sham controls at ages(n) 0(3), 2(3), 4(4), 6(4) and 8(3) weeks of age. TmPAH, Cin, CPAH, PAH extraction (EPAH) and dry kidney weight(DKW) were determined. In the paired control animals, TmPAH(r=.95)*, Cin(r=.97)*, CPAH(r=.92)*. CPAH/ EPAH(r=.95)* and TmPAH/Cin(r=.90)* increased with age. Filtration fraction(FF) and CPAH/EPAH/gDKW did not change with age. Immediately after nephrectomy and at 2 weeks, the experimental animals exhibited significant differences from controls in DKW, TmPAH and Cin, however, these differences were not apparent at or beyond 4 weeks. Neither TmPAH/gDKW, TmPAH/Cin, EPAH, FF nor CPAH/EPAH/g DKW were different between studies at any age, even though DKW was always less than controls and the DKW of the intact right experimental kidney was significantly greater than the right kidney of controls. It is apparent that the developing kidney is appropriate and adequate to functionally compensate for nephron loss at birth and does so while maintaining normal developmental GT relationships for PAH.* p<.001 |
