| Autor: |
Dangman, Barbara C, Rosen, Tove S, James, L S |
| Zdroj: |
Pediatric Research; April 1977, Vol. 11 Issue: 4 p415-415, 1p |
| Abstrakt: |
MgSO4 remains a commonly used therapy for obstetric patients with pre-eclampsia or premature labor, but little is known of its effects on the newborn. We studied plasma magnesium (Mg) levels and urinary excretion of Mg during the first 7 days of life in 16 premature and 5 full term infants of mothers treated with Mg. Clinical symptomatology consisted of mild hypotonia in 11 cases and did not correlate with peak plasma levels. The maternal plasma Mg level at delivery was 4.2±0.28 mg/dl (M±SE) and the ratio of maternal to umbilical artery (UA) values was 1.14. The infants' plasma Mg rose from 3.68±0.20 mg/dl (UA) to 4.2±0.17 mg/dl at 2 hrs. of age (heel stick). Subsequent levels showed a linear plasma elimination with a correlation coefficient of -0.9533. The plasma t½ was 43.22 hrs. Levels did not reach a normal range (1.5 -2.5 mg/dl) until approximately 1 week of age. There were no significant differences in either peak plasma levels or rate of elimination between the following subgroups: infants of mothers 1) receiving a total of >50 gm vs <50 gm; 2)receiving MgSO4 for >24 hrs vs <24 hrs; 3)receiving Mg infusions at a rate of >1.5 gm/hr vs <1.5 gm/hr; 4)with plasma Mg concentrations >4 mg/dl vs <4 mg/dl; 5)who had pre-eclampsia vs those treated for premature labor only; and 6)premature vs full term infants. Urinary clearance (Mg/creatinine) varied widely and failed to show any consistent association with either plasma level or postnatal age. Thus Mg, in the doses administered and at the plasma concentrations attained, has a prolonged t½, but does not exert any major deleterious effects on the newborn. |
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