Optimization, characterization and in vitro/vivoevaluation of azilsartan nanocrystals

Autor: Ma, Jingjing, Yang, Yinxian, Sun, Yinghua, Sun, Jin
Zdroj: Asian Journal of Pharmaceutical Sciences; July 2017, Vol. 12 Issue: 4 p344-352, 9p
Abstrakt: Through formulation screening, the irregular-shaped azilsartan nanocrystals were prepared and optimized by bead milling method and solidified by freeze-drying. The best formulation which had the size of 300 nm was expressed in its state by the studies of morphology and crystal from. And azilsartan nanocrystals showed its improvement about in-vitrodissolution and in-vivobioavailability with physical mixture as reference.
Databáze: Supplemental Index