| Autor: |
Karmakar, Kajari, Narita, Yuichi, Fadok, Jonathan, Ducret, Sebastien, Loche, Alberto, Kitazawa, Taro, Genoud, Christel, Di Meglio, Thomas, Thierry, Raphael, Bacelo, Joao, Lüthi, Andreas, Rijli, Filippo M. |
| Zdroj: |
Cell Reports; January 2017, Vol. 18 Issue: 1 p185-197, 13p |
| Abstrakt: |
Tonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input topography and sound transmission were largely preserved. However, fine-scale synaptic refinement and sharpening of isofrequency bands of cochlear neuron activation upon pure tone stimulation were impaired in Hox2mutants, resulting in defective sound-frequency discrimination in behavioral tests. These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit. |
| Databáze: |
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