The metabolism of intra-amniotically injected dehydroepiandrosterone as a placental function test

Autor: Hausknecht, Richard U., Mandelman, Nathan
Zdroj: American Journal of Obstetrics and Gynecology; June 1969, Vol. 104 Issue: 3 p433-435, 3p
Abstrakt: In the past 10 years urinary estriol excretion in the pregnant human female has been utilized as an index of fetoplacental health with increasing frequency. However, most investigators have failed to demonstrate a major improvement in neonatal mortality rates when this assay has been used. The intra-amniotic instillation of 200 mg. of dehydroepiandrosterone has been shown to bring about a pronounced rise in urinary estriol excretion. This indicates that the various enzyme systems in fetus and placenta are not fully saturated at term and that there is considerable metabolic reserve.
Databáze: Supplemental Index