| Autor: |
Narkates, A. J., Hunt, D. E. |
| Zdroj: |
Experimental Biology and Medicine; March 1973, Vol. 142 Issue: 3 p948-953, 6p |
| Abstrakt: |
The availability of a unique strain of Streptococcus faecalis, designated S. faecalisAcb-r, allowed studies which revealed the subcellular mechanism by which 1-β-D-arabinofuranosyl cytosine (ara-c) inhibits the growth of this organism. In S. faecalisAcb-r, concentrations of 1.0 × 10-4or 3.5 × 10-4Mara-c strongly inhibited the synthesis of DNA while the synthesis of RNA and protein was not greatly diminished by the same concentrations of this inhibitor. Ara-c inhibited by approximately 60–90% the incorporation of various radiolabeled nucleic acid precursors into DNA but not to any marked extent the incorporation of these precursors into RNA. Among various nucleosides and nucleotides tested, only deoxy-cytidine prevented inhibition of S. faecalisAcb-r by ara-c. These observations indicate that the primary effect of ara-c on S. faecalisAcb-r is the inhibition of DNA synthesis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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