New bis(dithiocarboxylato)nitridotechnetium-99m radiopharmaceuticals for leucocyte labelling: In vitro and In vivo studies

Autor: Demaimay, F., Noiret, N., Roucoux, A., Patin, H., Bellande, E., Pasqualini, R., Moisan, A.
Zdroj: Nuclear Medicine and Biology; 1997, Vol. 24 Issue: 5 p439-445, 7p
Abstrakt: Dithiocarboxylate ligands were synthesized and characterized. New nitrido 99m-technetium complexes were obtained with these ligands and identified by thin layer chromatography. The nitrido complexes were tested in vitro in whole blood for leucocyte labelling and the design of the ligand was optimized. Best results were obtained with aliphatic linear ligands, containing 9 to 11 atoms of carbon. The in vivo experiment failed because an inflammated area could not be visualized by γ imaging, the cell labelling mechanism being probably different.
Databáze: Supplemental Index