| Autor: |
Bordoni, Alessandra, Biagi, Pier Luigi, Rossi, Carlo Alfonso, Hrelia, Silvana |
| Zdroj: |
Biochemical and Biophysical Research Communications; January 1991, Vol. 174 Issue: 2 p869-877, 9p |
| Abstrakt: |
The fatty acid pattern of phosphatidylinositol and other inositol phospholipids is reported to be predominantly 1-stearoyl, 2-arachidonyl. However, literature does not report data about the effect of a modification of this fatty acid composition on the production and acidic pattern of the diacylglycerol (DAG) formed during phosphoinositide hydrolysis. Culturing cardiomyocytes in a docosahexaenoic acid supplemented medium, we obtained an homogeneous cell population whose phospholipid fatty acid pattern was strongly different from control cells, and which produced, after α1-adrenergic stimulation with phenylephrine, an higher amount of DAG. This DAG was different from control DAG in fatty acid composition, too. This structurally different DAG could be responsible for a different activation pattern of protein kinase C. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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