“Subclinical” Dosages of Lithium and Pilocarpine that Do Not Evoke Overt Seizures Affect Long-Term Spatial Memory but Not Learning in Rats

Autor: Cook, L. L., Persinger, M. A.
Zdroj: Perceptual & Motor Skills; June 1998, Vol. 86 Issue: Supplement 3 p1288-1290, 3p
Abstrakt: After training in an automated radial maze, 11 male rats were injected with either “subclinical” dosages of lithium and pilocarpine or saline and then tested 5 days or 4 months later. When employed as their own controls or when compared with a saline-injected reference group, the rats that had received the lithium and pilocarpine displayed memory deficits but not learning deficits after the longest of the two delays (effect size was 41%). These results suggest that subtle disruptions in memory but not learning to criterion could be associated with “subclinical electrical seizures” or the micromorphological changes associated with this activity.
Databáze: Supplemental Index