| Autor: |
Eckmier, Adam, Daney de Marcillac, Willy, Maèître, Agnès, Jay, Thèîérèîéèse M., Sanders, Matthew J., Godsil, Bill P. |
| Zdroj: |
Learning & Memory; 2016, Vol. 23 Issue: 12 p684-688, 5p |
| Abstrakt: |
Rodents are exquisitely sensitive to light and optogenetic behavioral experiments routinely introduce light-delivery materials into experimental situations, which raises the possibility that light could leak and influence behavioral performance. We examined whether rats respond to a faint diffusion of light, termed caplight, which emanated through the translucent dental acrylic resin used to affix deep-brain optical cannulas in place. Although rats did not display significant changes in locomotion or rearing to caplight in a darkened open field, they did acquire conditional fear via caplight-footshock pairings. These findings highlight the potential confounding influence of extraneous light emanating from light-delivery materials during optogenetic analyses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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