| Autor: |
Ruffin, R.E., Wolff, R.K., Dolovich, M.B., Rossman, C.M., Fitzgerald, J.D., Newhouse, M.T. |
| Zdroj: |
Chest; April 1978, Vol. 73 Issue: 4 p501-506, 6p |
| Abstrakt: |
The anticholinergic bronchodilator drug, Sch 1000, was administered as an aerosol by a metered-dose inhaler (200μg) to six normal and six bronchitic subjects. The short-term effect on mucociliary clearance was assessed and compared to a placebo (propellant and dispersal agent) in a double-blind crossover study. Mucociliary clearance in the normal group was significantly faster with administration of Sch 1000 than with placebo (P < 0.01). There was no significant difference between the effects of administration of Sch 1000 and placebo on mucociliary clearance in the bronchitic group. Pulmonary function was significantly increased by therapy with Sch 1000 (as compared to administration of placebo) in the bronchitic group for two hours (P < 0.05) and in the normal group for one hour (P < 0.05). In another study, 12 normal subjects inhaled aerosols containing 40μg of placebo or 400µg of Sch 1000 from metered-dose inhalers on separate days in a randomized double-blind fashion. A significant sustained improvement in pulmonary function (P < 0.05) and a transient fall in diastolic blood pressure were observed after administration of Sch 1000. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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