| Autor: |
Ghafouri, Mo A, Patil, Kashinath D., Kass, Irving |
| Zdroj: |
Chest; September 1984, Vol. 86 Issue: 3 p387-393, 7p |
| Abstrakt: |
Long-term effects of ipratropium bromide (IB) were evaluated using a double-blind cross-over design in 23 adult chronic bronchitic participants. Two 20-μg doses of either IB or placebo were administered as an inhalant four times a day for a period of seven weeks. Sputum volume expectorated during a 24-hour period decreased significantly (p<0.05) over the entire length of the study, but sputum viscosity or its dry weight were not affected. Although total number of inflammatory cells in sputum was decreased by the use of IB (p<0.05), macrophages increased slightly. Subjects coughed less while receiving IB, and their cough was less severe (p<0.05). Ipratropium bromide caused a significant improvement (p<0.05) in the mechanics of breathing primarily in the subjects between 46 to 55 years of age. No major adverse reaction to IB was recorded. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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