| Autor: |
LEWIS, WILLIAM C., CALDEN, GEORGE, THURSTON, JOHN R., GILSON, WARREN E. |
| Zdroj: |
Diseases of the Chest; August 1957, Vol. 32 Issue: 2 p172-182, 11p |
| Abstrakt: |
Of 30 patients placed on cycloserine, half showed some type of psychiatric or neurologic change of varying severity. Six showed severe disturbance of function, either manifested by mounting signs of central nervous system instability culminating in grand mal convulsion (three patients) or in borderline or outright psychoses (three patients). Psychological test results of the “normal” group (i.e., those not showing obvious psychiatric symptoms) did not show significant alterations in mood and attitude during the course of treatment. Repeated EEG's were normal except in only one case despite the occurrence of seizures in three. Some of the difficulties involved in assessing the role of cycloserine in the causation of these changes are described, and typical cases are presented together with data regarding blood cycloserine levels. In any future attempt to evaluate cycloserine toxicity it appears to be essential to obtain as normal a sample of cases as possible, and pending such studies, cycloserine treatment of psychiatrically disturbed persons should be undertaken with considerable caution. |
| Databáze: |
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