| Autor: |
Lavine, Steven J., Prcevski, Petar, Held, A.Christian, Johnson, Vicki |
| Zdroj: |
Journal of the American College of Cardiology; December 1991, Vol. 18 Issue: 7 p1794-1803, 10p |
| Abstrakt: |
A model of chronic left ventricular dysfunction characterized by left ventricular dilation, elevated filling pressures and histologic changes has been lacking. In this study the use of coronary microsphere embolization-induced ischemia was explored as a method of producing chronic left ventricular dysfunction. Acute ischemic left ventricular dysfunction was induced in 13 mongrel dogs with 50 μn plastic microspheres until the peak positive first derivative of left ventricular pressure (dP/dt) decreased by 25% and the left ventricular end-diastolic pressure increased to ≥12 mm Hg. After 8 weeks of observation, hemodynamic and echocardiographic variables were measured in each dog. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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