| Autor: |
Kushwaha, Sudhir S., Crossman, David C., Bustami, Mahmud, Davies, Graham J., Mitchell, Andrew G., Maseri, Attilio, Yacoub, Magdi H. |
| Zdroj: |
Journal of the American College of Cardiology; June 1991, Vol. 17 Issue: 7 p1537-1544, 8p |
| Abstrakt: |
The endothelium-dependent vasodilator substance P dilates normal and diseased coronary vessels in humans in vivo and produces a maximal response similar to that seen with intracoronary isosorbide dinitrate. Twelve cardiac transplant recipients underwent intracoronary infusion of substance P after routine annual investigations. All patients were well, with no evidence of rejection and with angiographically normal coronary arteries. Substance P was infused at 2 ml/min for 2 min into the coronary artery, starting at a dose of 1.4 pmol/min and increasing by doubling increments, and followed by isosorbide dinitrate (1 mg/min) infused over 2 min. Coronary artery diameter was measured in 23 vessel segments from 12 transplant recipients. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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