| Autor: |
Epstein, Andrew E., Bigger, J. Thomas, George Wyse, D., Romhilt, Donald W., Reynolds-Haertle, Robin A., Hallstrom, Alfred P. |
| Zdroj: |
Journal of the American College of Cardiology; July 1991, Vol. 18 Issue: 1 p14-19, 6p |
| Abstrakt: |
To test the hypothesis that suppression of ventricular arrhythmias by antiarrhythmic drugs after myocardial infarction improves survival, the Cardiac Arrhythmia Suppression Trial (CAST) was initiated. Suppression was evaluated before randomization during an open label titration period. Patients whose arrhythmias were suppressed were randomized in the main study and those whose arrhythmias were partially suppressed were randomized in a substudy. Overall survival and survival free of arrhythmic death or cardiac arrest were higher in patients treated with encainide or flecainide than in patients treated with placebo. However, the death rate in patients randomized to placebo therapy was lower than expected. This report describes the survival experience of all patients enrolled in CAST and compares it with mortality in other studies of patients with ventricular arrhythmias after myocardial infarction. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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