Early thrombolysis in acute myocardial infarction: Limitation of infarct size and improved survival

Autor: Simoons, Maarten L., Serruys, Patrick W., van den Brand, Marcel, Res, Jan, Verheugt, Freek W.A., Krauss, X. Hanno, Remme, Willem J., Bär, Frits, Zwaan, Chris de, Laarse, Arnoud van der, Vermeer, Frank, Lubsen, Jacobus
Zdroj: Journal of the American College of Cardiology; April 1986, Vol. 7 Issue: 4 p717-728, 12p
Abstrakt: The effect of thrombolysis in acute myocardial infarction on infarct size, left ventricular function, clinical course and patient survival was studied in a randomized trial comparing thrombolysis (269 patients) with conventional treatment (264 control patients). All 533 patients were admitted to the coronary care unit within 4 hours after the onset of symptoms related to the infarction. Baseline characteristics were similar in both groups. Informed consent was requested only of patients allocated to thrombolysis; no angiography was performed in 35. The infarct-related artery was patent in 65 patients and occluded in 169. Recanalization was achieved in 133 patients. The median time to angiographic documentation of vessel patency was 200 minutes after the onset of symptoms.
Databáze: Supplemental Index